Environmental Toxicology

Paper Code: 
DENV 501B
Credits: 
04
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

This course will enable the students to –

  1. Make students familiar with the basic principles of environmental toxicology, including aspects of exposure, toxicity and risk assessment of chemicals in the environment.
  2. Gain skills for assessing the toxico-kinetics and toxicity of pollutants in biological and environmental systems

Course Outcomes (COs):

Course

Course outcome

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

DENV 501B

 

Environmental Toxicology

Upon completion   of

this course, students

will:

CO41: Differentiate the

natural                     and

anthropogenic sources of

toxicants        in        the

environment

CO42:       Judge       the

mechanisms                          causing toxicity of chemicals in

human                     and

environmental

components

CO43: Develop skills to

remediate the problem

of environmental toxicity

CO44:      Develop               the various                 sustainable

methods                    for

environmental remediation

Approach                          in teaching:

Explicit teaching, Interactive Lectures, Group Discussions, Use of informative videos

Learning activities for the students: Preparation of notes by using reference books, Power point presentations, Weekly                        class assessment

PowerPoint presentations, Assignments, Class Tests, Semester end examinations

 

12.00
Unit I: 
Introduction, Scope and Importance of Toxicology
  • Areas and Branches of toxicology
  • Scope and importance
  • Types of toxicants
  • Molecular and biochemical effects of toxicants

 

12.00
Unit II: 
Basic concept of Toxicology
  • Dose of Toxicants
  • Effect and response – (acute effects, chronic effects, reversible and irreversible effects and local and systemic effects)
  • Dose response relationship – (graded and quantal response)
  • Absorption, Distribution and Excretion (Basic concept)
  • Bioaccumulation of Xenobiotics
12.00
Unit III: 
Transport and Fate of Toxicants in the Environment
  • Sources of Toxicants to the Environment
  • Transport Processes: Advection & Diffusion
  • Transformation Processes
    • Reversible Reactions (Ionization, Precipitation and Dissolution, Complexation and Chemical Speciation)
    • Irreversible    Reactions (Hydrolysis,   Photolysis, Oxidation-Reduction reactions, Bio-transformations)

 

12.00
Unit IV: 
Toxicity of Metals
  • Sources and toxic effects on humans of
    • Arsenic
    • Lead
    • Cadmium
    • Mercury
  • Toxicity of Pesticides: Organochlorines and Organophosphates Insecticides

 

12.00
Unit V: 
Food Additives and Contaminants
  • Incidental or indirect additives
  • Intentional or direct additives
    • Antioxidants
    • Flavouring Agents
    • Colour and preservatives
  • Food Toxins
    • Microbial toxins-algal, fungal and bacterial toxins
    • Plant toxins

 

Essential Readings: 

ESSENTIAL READINGS

  • Casarett, & Doull’s. (2008). Toxicology: The Basic Science Of Poisons (7th Ed.). New York: Mcgraw-Hill.
  • Hodgson, E. (2010). A Textbook Of Modern Toxicology. A John Wiley & Sons, Inc.
  • Pandey, K., Shukla, J. P., & Trivedi, S. P. (2011). Fundamentals Of Toxicology. New Central Book Agency.
  • Sharma, P. (2005). Environmental Biology And Toxicology. Meerut: Rastogi Publication.
  • Shaw, I., & Chadwick, J. ( 1998). Prinicples Of Environmental Toxicology. Taylor & Francis Ltd.
  • Wright, D. A., & Welbourn, P. (2002). Environmental Toxicology. New York: Cambridge University Press.

SUGGESTED READINGS

  • Helferich, W., & Winter, C. K. (2001). Food Toxicology. Crc Press
  • Hughes, W.W(1196)ESSENTIALS OF ENVIRONMENTAL TOXICOLOGY: The Effects of Environmentally Hazardous Substances on Human Health .Taylor & Francis.
  • Roberts, S.M., James,R.C. and. Williams,P.L(2015) Principles of Toxicology Environmental and Industrial Applications. Wiley publications

 

References: 

e- RESOURCES

JOURNALS

  • Journal of toxicology and health
  • Journal of Applied toxicology
  • Toxicology research
Academic Year: 
2023-2024
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